https://www.zychenlab.org/research daily 1.0 2025-04-27 https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/1657159176416-93PD0M5UD9JKNEO5SP5O/220706_embryo_for_website.png RESEARCH - A new life begins at fertilization of the egg by the sperm. Following fertilization, the terminally differentiated gametes are converted into a totipotent zygote. During parental-to-zygotic transition, much of the parental epigenomes are reset except for imprinted loci. This resetting process is known as epigenetic reprogramming. Our lab aims to understand epigenetic reprogramming by studying 1) chromatin dynamics and functions during parental-to-zygotic transition, 2) key factors required for totipotency acquisition, and 3) biological significance of transposon expression dynamics in early development. In addition, we also focus on mechanisms underlying the lineage and cell type-specific genomic imprinting. Mouse early development (Created with BioRender.com) https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/1657201694150-MF3Q4LFRX6UY8E9FGNTE/220331_Summary_of_Polycomb_landscape.png RESEARCH - Make it stand out Chen et al., 2021 Nature Genetics https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/0c077bc4-4b39-4fad-a28e-3850314512f3/240109_MT2i_graphic_abstract.jpg RESEARCH Systematic evaluation of cis-regulatory functions of MT2 elements in mouse embryos (Cell Reports, 2024) https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/1657381214707-031GCXZYP1Q77T5BC5E9/220709_imprints_cycle.png RESEARCH - Make it stand out The cycles of canonical (left) and non-canonical (right) imprints (Chen et al., 2020 Nature Review Genetics) https://www.zychenlab.org/people daily 0.75 2026-03-18 https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/2af5dd33-540d-40bc-aed6-a72cca2d9140/headshot.jpeg PEOPLE https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/92d28ef9-be72-4ac3-9a07-350b168f2382/neha+profile-pic+.jpg PEOPLE https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/3a9d77c9-8f49-4fc0-ac94-1258e0d29199/Lauryn+Cook--Headshot.jpeg PEOPLE https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/9d5cc1fd-1961-413f-81ac-e5e03dc1a5c9/Screenshot+2024-03-25+at+8.58.09%E2%80%AFPM.jpg PEOPLE https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/fedae320-e01d-4e7d-b941-1c204f918bfe/Pfaltzgraff%2BNatalie.jpg PEOPLE https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/8bc799a7-4be9-426d-8c8d-ef59f1f1ac42/1S8A6595.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/92255de2-77a5-4239-9eb7-22e15ffa0e18/Picture1.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/6f59df2c-cd55-445f-92fb-27012e430ddc/image001.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/0ee4c7c3-c8ae-4eda-8476-f60a54251fd2/image001.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.zychenlab.org/new-page daily 0.75 2026-03-27 https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/4b9b4de0-6d03-4229-8383-5b08a34eb172/Screenshot+2026-03-26+at+8.44.21%E2%80%AFPM.png NEWS - 03/13/2026 Jinwen received The Lalor Foundation fellowship to support his research in understanding PR-DUB function in female fertility! Big congratulations! https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/159f2214-82b4-4365-93d4-50efdf407518/2026_SSR+rising+star.png NEWS - 02/11/2026 ZY is honored to give a seminar in 2026 SSR Rising Stars Webinar! https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/17745af1-ac55-4829-b220-d5e6d2b1f678/IMG_8288.jpg NEWS - 08/04/2025 We are excited to share our recent work in the Society for the Study of Reproduction annual conference in Washington DC. https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/54e6c829-86a6-4e5c-9802-10ac71b088b9/Screenshot+2025-06-07+at+11.54.56%E2%80%AFAM.png NEWS - 06/05/2025 We are thrilled to receive a 5-year NIH R01 award to support research on understanding the gene regulatory roles of long terminal repeat (LTR) retrotransposons in mouse early development using (epi)genome editing and multi-omics analyses. https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/c4580d14-e226-46e3-9ac1-630ed700767c/Screenshot+2025-06-07+at+11.43.15%E2%80%AFAM.jpg NEWS - 05/28/2025 We contributed a protocol on chromatin analyses during Zygotic Genome Activation in mouse embryos. Cheers! https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/e1f9b447-c6ef-4f49-8934-5faefba04814/2026_mizzou.jpg NEWS - 02/05/2025 ZY is honored to give a talk at the University of Missouri, Columbia! Proud to be a Mizzou alumni—Go Tigers! https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/b71b6701-ce4f-45de-97cf-02bff8d4d594/Pic2.jpg NEWS - 01/24/25 Many things to celebrate this day! Welcome Jinwen and Shoko! Lauryn’s and Peiyao’s graduate school offers! Lunar/Chinese New Year! https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/cc249b49-c6d6-4ad6-9c39-cb853de920a8/Screenshot+2024-02-21+at+8.03.53%E2%80%AFPM.jpg NEWS - 02/20/2024 Jian and Lauryn’s paper is online today! Congratulations! https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/5250c6e4-2f00-4843-9712-10648fd188ae/240111_cake.jpg NEWS - 01/11/2024 Celebration of the first Chen lab paper “in principle“ acceptance! Cheers! https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/b21a1e2d-7018-412e-8a59-384576324af2/2023_lab_pic.jpg NEWS - 12/22/2023 Celebration of the holidays! https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/24c81c9c-71d4-479a-a65a-5f5a8f48f435/Screenshot+2025-06-07+at+12.02.02%E2%80%AFPM.png NEWS - 12/12/2023 We are excited to receive the Trustee Award ($200k over two years) from Cincinnati Children’s Research Foundation for studying retrotransposon function in mammalian early development. https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/b9610f82-87e6-45b1-9a09-4cac08b8032b/Screenshot+2025-06-07+at+11.54.56%E2%80%AFAM.png NEWS - 01/03/2023 We successfully made the K99-to-R00 transition! The 3-year R00 award will support research to systemically dissect the mechanisms and functions of PcG proteins in mouse early development using the cutting-edge low-input chromatin profiling and rapid protein degradation techniques. https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/88761954-05a6-4095-8cfc-887e3bc5cdf7/WechatIMG350.jpeg NEWS - 01/03/2023 Chen Lab was officially launched!! https://www.zychenlab.org/publications daily 0.75 2026-03-18 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg PUBLICATIONS https://www.zychenlab.org/contact daily 0.75 2023-01-05 https://www.zychenlab.org/gallery daily 0.75 2025-02-01 https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/6e9895e9-1e72-4ea7-b8da-266875702f13/MII_injection.png GALLERY https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/27f539ff-09c7-41af-97ce-bc4371f841b8/E7.5.png GALLERY https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/ba42f293-772d-4206-a1ee-d952a58e7c0f/draft2.png GALLERY https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/6e654820-3b72-437c-b47b-f8def9c743fe/E9.5_GFP.png GALLERY https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/3676c654-6ded-4463-b07b-3d2bfbf04019/BL_IF1.png GALLERY https://images.squarespace-cdn.com/content/v1/62bba6f040e963662c07996c/1657409412633-IUG595VFCX69UHO88HD8/GV_tracks.jpg GALLERY https://www.zychenlab.org/positions daily 0.75 2025-10-17